Distinct roles for IL-13 and IL-4 via IL-13 receptor 1 and the type II IL-4 receptor in asthma pathogenesis

Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.

IL-13 and IL-4 are central T helper 2 (Th2) cytokines in the immune system and potent activators of inflammatory responses and fibrosis during Th2 inflammation. Recent studies using Il13ra1(-/-) mice have demonstrated a critical role for IL-13 receptor (IL-13R) alpha1 in allergen-induced airway responses. However, these observations require further attention especially because IL-4 can induce s...

association of the expression of il-4 and il-13 genes, il-4 and ige serum levels with allergic asthma

immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. these responses are associated with overexpression of th2 cytokines such as il-4 and il-13. these two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the th1/th2 balance. the aim of this study was to determine whether patient...

The Type I and Type II Receptor Complexes for IL-4 and IL-13 Differentially Regulate Allergic Lung Inflammation

Signaling of IL 4 and IL 13 Genetic Variants in Asthma Pathogenesis

Prevalence of chronic disorder like asthma has dramatically increased in recent decades. These are mainly disorder of immune system, the results of complex interactions among various genetic and environmental factors. Interleukin 4 and 13, a Th2type cytokine play key role in inflammatory pathway, emerged in the pathogenesis of bronchial asthma. Both are act as central regulator in IgE synthesis...

IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype.

The chemokine thymus- and activation-regulated chemokine (TARC) induces selective migration of Th2, but not Th1, lymphocytes and is upregulated in the airways of asthmatic patients. The purpose of this study was to determine whether human airway smooth muscle (HASM) cells produce TARC. Neither IL-4, IL-13, IL-1beta, IFN-gamma, nor TNF-alpha alone stimulated TARC release into the supernatant of ...